解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Clara cell protein (CC16) is an endogenous anti-inflammatory agent. It is produced mainly in the respiratory and urogenital tracts. CC16 has been quantified in serum, but not in cerebrospinal fluid (CSF). The aim of this study was to examine CSF CC16 in relation to age, gender and serum CC16, and to examine CC16 level...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0318
更新日期:1998-06-01 00:00:00
abstract::Interleukin 2 (IL-2)- and IL-4-mediated stimulation of survival and growth, reflected by the induction of bcl2 and c-myc, respectively, depends on the integrity of the membrane-proximal region (S-region) in the IL-2 receptor beta-chain (IL-2R beta) and the haematopoietin homology box1-containing region of the IL-4 rec...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0293
更新日期:1998-05-01 00:00:00
abstract::Tumour necrosis factor alpha (TNF-alpha) plays an important role in orchestrating inflammatory responses with the vascular endothelium as main target cell type, and was found to promote migration of endothelial cells, as occurs in wound healing processes. Substantial evidence exists that endothelial cell migration in ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0287
更新日期:1998-04-01 00:00:00
abstract::Osteoclasts, the main protagonists involved in bone resorption mechanisms, are generally considered to be of haematopoietic origin, although the exact nature of the primary osteoclastic stem cells is still unknown. In vitro cellular models developed to study the different events of osteoclastic differentiation have re...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1006/cyto.1997.0277
更新日期:1998-03-01 00:00:00
abstract::The authors studied plasma cytokine activity using cross reactive polyclonal antibodies to human cytokines in young and old female monkeys to determine if age had any effect on cytokine secretion, and compared hormonal effects as well. While interleukin 1 (IL-1) was not higher in aged cycling monkeys, it was after men...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0281
更新日期:1998-03-01 00:00:00
abstract::Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0264
更新日期:1998-02-01 00:00:00
abstract::Interleukin 6 (IL-6) and related gp130-signalling cytokines rapidly activate latent cytoplasmic Stat transcription factors and these are believed to play pivotal roles in the expression of downstream cytokine-responsive genes. We have previously shown in IL-6-deficient (-/-) mice that IL-6 is absolutely required for t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0250
更新日期:1998-01-01 00:00:00
abstract::Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. The present study was designed to assess whether mycobacterial components were able to induce expression and production of MCP-3 in human monocytes. Mycobacter...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0242
更新日期:1997-12-01 00:00:00
abstract::Murine fibrosarcoma L929 cells were transfected with human Fas cDNA. The mode of cell death was analysed following treatment either with tumour necrosis factor (TNF) or with agonistic antibodies to Fas. While triggering of the TNF receptors led to necrosis, clustering of the Fas antigen resulted in apoptotic cell deat...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0252
更新日期:1997-11-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0233
更新日期:1997-10-01 00:00:00
abstract::Cytokine profiles were studied during 19 episodes of chemotherapy-induced neutropenia in 17 patients with haematological malignancies. Circulating concentrations of interleukin 1 alpha (IL-1 alpha), tumour necrosis factor alpha (TNF-alpha) and IL-1 receptor antagonist (IL-1ra) were measured before chemotherapy and the...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0223
更新日期:1997-09-01 00:00:00
abstract::The eph family is the largest subfamily of receptor tyrosine kinases (RTKs). Members of this subfamily display specific expression in the developing and adult brain. Recently, cDNAs encoding membrane bound ligands for these receptors have been identified which we have termed LERKs (ligand for eph-related kinases). We ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0199
更新日期:1997-08-01 00:00:00
abstract::We have studied the effects of rhTGF-beta2, dexamethanosome (dex) and 1,25(OH)2D3 on human bone marrow stromal (HBMS) cells in long-term culture. A fraction on HBMS expressed type I collagen (Col I) and osteopontin, and transient treatment (48 h) with dex increased the number of alkaline phosphatase (ALP) positive cel...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0209
更新日期:1997-08-01 00:00:00
abstract::Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0191
更新日期:1997-07-01 00:00:00
abstract::Interleukin 15 (IL-15) is a cytokine with many functional characteristics that are similar to IL-2. Most of the functional activities that IL-2 and IL-15 support have been evaluated in short-term assays. It was our intention, then, to determine the long-term effects of IL-15 in comparison to IL-2. These studies were p...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0171
更新日期:1997-05-01 00:00:00
abstract::Tumour necrosis factor (TNF) is a pleiotropic cytokine which plays a central role in infection, inflammation and autoimmune diseases. Its functions are mediated through binding to high affinity cell surface receptors. An approach to modulate excessive levels of TNF-alpha in the serum is the use of soluble receptors. I...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0158
更新日期:1997-04-01 00:00:00
abstract::The authors describe the design and validation of a competitive RT-PCR method for the efficient and reproducible quantitation of mRNA molecules of IFN-gamma, TNF-alpha, IL-4 and IL-10 in mouse spleen RNA extracts. Before being subjected to RT-PCR, the RNA extracts were supplemented with internal control RNAs (IC-RNAs)...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0156
更新日期:1997-03-01 00:00:00
abstract::Using different binding assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a high-affinity site characterized by a dissociation constant (Kd) of 0.3 nM. This interaction was confirmed by native polyacrylamide gel electrophoresis, which ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0142
更新日期:1997-02-01 00:00:00
abstract::The purpose of this study was to clone and characterize the bovine IL-1rII. Using a human IL-1rII probe, three putative exons of the bovine IL-1rII were identified from a bovine genomic library. The full length cDNA for bovine IL-1rII was cloned from a bovine endometrial cDNA library using oligonucleotides designed fr...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0129
更新日期:1997-01-01 00:00:00
abstract::Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 microg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0123
更新日期:1996-12-01 00:00:00
abstract::The supernatant from normal liver cell (Clone 1469) culture enhanced polyclonal antibody production in mouse spleen cells but not in human peripheral blood lymphocytes. The supernatants from transforming growth factor beta (TGF-beta)-treated C3H/HeN spleen cells augmented greatly polyclonal antibody responses compared...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0112
更新日期:1996-11-01 00:00:00
abstract::The authors have shown previously that in addition to its survival effects on neurons and glia, ciliary neurotrophic factor (CNTF) induced potent cachectic effects and acute phase proteins when present in the peripheral circulation at concentrations of < or = 10 ng/ml. These effects did not depend upon the induction o...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0104
更新日期:1996-10-01 00:00:00
abstract::The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0092
更新日期:1996-09-01 00:00:00
abstract::The present study aims to characterize the role of the citrulline-nitric oxide cycle in the response of adult human and rat pancreatic islets to cytokines. Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 bet...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0086
更新日期:1996-08-01 00:00:00
abstract::Specific high titre polyclonal antibodies rapidly obtained by intralymphnode immunization of rabbits with recombinant M-CSF and LIF (< 60 micrograms/animal) have been used to develop specific, accurate and sensitive EIAs. The same batch of purified anti-M-CSF or anti-LIF Igs has been used for the coating of 96-well pl...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0078
更新日期:1996-07-01 00:00:00
abstract::The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0060
更新日期:1996-06-01 00:00:00
abstract::Within the human TNF promoter we have identified two sites at positions -189 and -101 that show C/EBP specific binding of nuclear proteins from cells of the human monocytic line Mono Mac 6. Supershift analysis with anti C/EBP antibodies revealed that the complexes formed consist of both C/EBP alpha and C/EBP beta. Whe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0046
更新日期:1996-05-01 00:00:00
abstract::Leukaemia inhibitory factor (LIF), a pleiotropic cytokine detected in various inflammatory body fluids, plays a poorly defined role in the pathogenesis of human disease. This study was conducted to correlate the LIF concentrations in pleural effusions with the type of pathology and to compare its levels with those of ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0056
更新日期:1996-05-01 00:00:00
abstract::IL-4 promotes simultaneous expression of both the CD23 and CD25 antigens in resting human B lymphocytes in a dose-dependent manner. Simultaneous three-colour flow cytometric analysis revealed that CD19+/CD23+/CD25+ triple-positive cells were derived from a CD19+/CD23-/CD25- pool, and that induction of CD23 required lo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0041
更新日期:1996-04-01 00:00:00
abstract::Interleukin 5 (IL-5) is a T-cell derived cytokine that induces eosinophil growth and differentiation in both mouse and human bone marrow cultures. Elevated levels of IL-5 as well as eosinophils have been detected in the sputum and Bronchoalveolar lavage (BAL) fluids of asthmatics. Since the recruitment of inflammatory...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0034
更新日期:1996-03-01 00:00:00
abstract::Intraarticular injection of zymosan (1 mg) into the knee joints of male Wistar rats led to infiltration of neutrophils and monocytes, joint swelling and elevation of tumour necrosis factor (TNF-alpha) in joint lavage fluids. Neutrophil infiltration was maximal at 5 h after induction of arthritis but had declined by 24...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0018
更新日期:1996-02-01 00:00:00
abstract::The N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP), a unique cytokine present in human granulocytes, was determined to be: Pyroglu-Leu-Lys-X-Tyr-Thr-X-Lys-Glu-Pro-Met-Thr-Ser(Thr)-Ala-Ala... This sequence showed no significant homology with any other protein when used in database searches...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0001
更新日期:1996-01-01 00:00:00
abstract::Psoriatic fibroblasts produce enhanced amounts of IL-6 in vitro. This state of activation may reflect an altered expression of cytokine receptors, involved in auto/paracrine induction of IL-6. Cultures of dermal fibroblasts derived from lesional psoriatic (PP) and normal control (NN) skin were therefore analysed for t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0011
更新日期:1996-01-01 00:00:00
abstract::It is well known that interleukin (IL)-1 is a potent activator of the hypothalamo-pituitary-adrenal axis in the rat. Many studies have reported that prostaglandins (PGs), especially PGE2, in the brain may mediate the IL-1 stimulation of corticotropin-releasing hormone release, which then leads to adrenocorticotropin (...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0083
更新日期:1995-10-01 00:00:00
abstract::Malignant ascites of epithelial ovarian cancer patients contains high levels of interleukin 6 (IL-6). The present study was conducted to compare the secretion of IL-6 by seven different human ovarian cancer cell lines (OVCA) and cultured human peritoneal mesothelial cells (HPMC) and to examine the regulation of its pr...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0073
更新日期:1995-08-01 00:00:00
abstract::The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response. The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established. However, the mechanism(s) by which priming oc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0058
更新日期:1995-07-01 00:00:00
abstract::In human interleukin 4(IL-4), the carboxyl and amino termini of the 129 amino acid hormone are close to each other and this region is believed to be important for binding to the IL-4 receptor (IL-4r). We constructed plasmids encoding circularly permuted IL-4 mutants with the peptide Gly-Gly-Asn-Gly-Gly (GGNGG) joining...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0039
更新日期:1995-05-01 00:00:00
abstract::It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0033
更新日期:1995-04-01 00:00:00
abstract::Cytotoxic action of leukocytes may be involved in the pathogenesis of inflammatory heart muscle disorders. We investigated the expression of rat leukocyte chemotactic cytokines--cytokine induced neutrophil chemoattractant (CINC) and JE--in cultured neonatal rat cardiac myocytes; CINC belongs to the interleukin 8 (IL-8...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0037
更新日期:1995-04-01 00:00:00
abstract::ICAM-1-mediated cell-cell adhesion is essential for different immunologic functions including non-MHC-restricted cytotoxicity. The shedding of a soluble form of ICAM-1 from melanoma impairs immune recognition and leads to tumour escape. Pretreatment of the Foss human melanoma cell line with HILDA/LIF or OSM, two cytok...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.1015
更新日期:1995-02-01 00:00:00